WHAT IT IS
ARESTIN® (minocycline hydrochloride) Microspheres, 1 mg is a locally administered antibiotic (LAA) that is indicated as an adjunct therapy to scaling and root planing (SRP) procedures for reduction of pocket depth in patients with adult periodontitis. ARESTIN® may be used as part of a periodontal maintenance program which includes good oral hygiene, and scaling and root planing.
Minocycline Microspheres make it different
ARESTIN® is a treatment for chronic periodontitis, an infection of the gums that can lead to tooth loss. Also, although a causal relationship between periodontal disease and an elevated risk for systemic events has not been established, recent evidence suggests there may be a link to other serious diseases such as cardiovascular disease, osteoporosis and diabetes.12 ARESTIN® uses Microsphere technology to easily and effectively kill the bacteria that can cause periodontal disease. ARESTIN® delivers minocycline in a unique powdered Microsphere delivery system that requires no preparation and is easy to administer. In fact, in clinical trials, dental professionals were able to treat as many as 30 sites in less than 10 minutes.5
ARESTIN® Microspheres are a bioadhesive, bioresorbable polymer in powder form produced by a microencapsulation process. Once ARESTIN® is administered, it immediately adheres to the periodontal pocket.
Crevicular fluid hydrolyzes the polymer causing water-filled channels to form inside the Microspheres. These holes provide "escape routes" for the encapsulated antibiotic for sustained release. The active drug dissolves and diffuses out of the Microspheres through the channels into the surrounding tissue. Eventually, the Microspheres themselves are fragmented through polymer hydrolysis and are completely bioresorbed.
ARESTIN® maintains therapeutic drug concentrations for up to 21 days, and the localized delivery provides an effective drug concentration at the site of infection.5
For more information about ARESTIN®, please see the full Prescribing Information.