ARESTIN® minocycline HCI 1mg Microspheres

MODE OF ACTION

ARESTIN^® (minocycline hydrochloride) Microspheres, 1 mg contains the antibiotic minocycline, a member of the tetracycline class of antibiotics. Minocycline exerts its antimicrobial activity by inhibiting protein synthesis and has been shown to be effective against the pathogens associated with periodontal disease.

How ARESTIN® Microspheres work

Once ARESTIN® is inserted, it immediately adheres to the periodontal pocket. Gingival crevicular fluid hydrolyzes the polymer, causing water-filled channels to form inside the Microspheres, allowing a controlled, sustained release of minocycline.

See ARESTIN® in Action

Minocycline effectively treats periodontal pathogens⁴

Minocycline achieves minimum inhibitory concentration (MIC) levels well above those reported for common periodontal pathogens, effectively treating the harmful bacteria that cause periodontal disease.²⁰

Adding ARESTIN® makes a significant difference

The leading locally administered antibiotic (LAA), ARESTIN®, delivers a sustained dose of minocycline—a broad-spectrum, semisynthetic tetracycline derivative—directly to infected pockets, helping to kill the bacteria that SRP can leave behind.⁴

• ARESTIN® provides safe, localized drug concentrations at the site of infection^1,4,21
• ARESTIN® helps maintain therapeutic drug concentrations in the periodontal pocket for up to 21 days⁵
• ARESTIN® stays in place after application and does not require removal